6-[(3-aminophenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3-4]pyrrolo[1-3-d]pyridazinone and Multiple-Sclerosis

6-[(3-aminophenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3-4]pyrrolo[1-3-d]pyridazinone has been researched along with Multiple-Sclerosis* in 1 studies

Other Studies

1 other study(ies) available for 6-[(3-aminophenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3-4]pyrrolo[1-3-d]pyridazinone and Multiple-Sclerosis

Article	Year
Modulation of PKM activity affects the differentiation of T Science signaling, 2020, 10-27, Volume: 13, Issue:655 Small molecules that promote the metabolic activity of the pyruvate kinase isoform PKM2, such as TEPP-46 and DASA-58, limit tumorigenesis and inflammation. To understand how these compounds alter T cell function, we assessed their therapeutic activity in a mouse model of T cell-mediated autoimmunity that mimics multiple sclerosis (MS). T Topics: Animals; Cell Differentiation; Female; Male; Mice; Mice, Knockout; Multiple Sclerosis; Pyridazines; Pyrroles; Pyruvate Kinase; Signal Transduction; Th17 Cells; Transforming Growth Factor beta1	2020

Article

Year

Modulation of PKM activity affects the differentiation of T

Science signaling, 2020, 10-27, Volume: 13, Issue:655

Small molecules that promote the metabolic activity of the pyruvate kinase isoform PKM2, such as TEPP-46 and DASA-58, limit tumorigenesis and inflammation. To understand how these compounds alter T cell function, we assessed their therapeutic activity in a mouse model of T cell-mediated autoimmunity that mimics multiple sclerosis (MS). T

Topics: Animals; Cell Differentiation; Female; Male; Mice; Mice, Knockout; Multiple Sclerosis; Pyridazines; Pyrroles; Pyruvate Kinase; Signal Transduction; Th17 Cells; Transforming Growth Factor beta1

2020